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Ingredient Guide

Palmitoyl Tetrapeptide-7 (CAS 221227-05-0): Supplier & Use Guide

Published 2026-07-07·4 min read

Palmitoyl Tetrapeptide-7 — INCI Palmitoyl Tetrapeptide-7, CAS 221227-05-0 — is a lipidated peptide widely used alongside Palmitoyl Tripeptide-1; together they form the well-known "Matrixyl 3000" style pairing for anti-aging skincare.

Key specifications

  • CAS No.: 221227-05-0
  • INCI: Palmitoyl Tetrapeptide-7
  • Appearance: white to off-white powder
  • Purity: cosmetic grade, HPLC assay on COA
  • Solubility: lipophilic due to the palmitoyl chain

Formulation notes

Effective at low active levels. Frequently blended with Palmitoyl Tripeptide-1. Disperse/solubilise appropriately, add during cool-down, keep pH mild, and validate the finished formula for stability and preservative efficacy. Store sealed, cool, dry and away from light.

Sourcing checklist

  • Batch COA with HPLC assay and method;
  • MSDS and an HPLC chromatogram for high-value lots;
  • MOQ, packaging and lead time;
  • A sample for bench testing.

WYOO supplies Palmitoyl Tetrapeptide-7, cosmetic grade, with COA and MSDS on every batch and MOQ from 1 kg. Contact us for a sample and pricing — and ask about the Pal-GHK / Pal-Tetra pairing.

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