Palmitoyl Pentapeptide-4 — INCI Palmitoyl Pentapeptide-4, the original "Matrixyl", also known as Pal-KTTKS, CAS 214047-00-4 — is one of the best-known matrikine peptides in anti-aging skincare. The palmitoyl chain is attached to the pentapeptide KTTKS to improve skin penetration.
Key specifications
- CAS No.: 214047-00-4
- INCI: Palmitoyl Pentapeptide-4
- Appearance: white to off-white powder
- Purity: cosmetic grade, HPLC assay on COA
- Solubility: lipophilic due to the palmitoyl chain
How it is used
Matrixyl-type peptides are effective at very low active levels. Many finished products use a pre-standardised solution; if you compound from powder, calculate to the equivalent active. It is commonly paired with Palmitoyl Tripeptide-1. Add in the cool-down phase, keep pH mild and avoid prolonged heat.
Formulation notes
- Disperse/solubilise appropriately; it is not freely water-soluble.
- Test the full formula for stability and preservative efficacy.
- Store sealed, cool, dry and out of light.
Sourcing checklist
- Confirm INCI, CAS and purity (HPLC method on the COA);
- Ask for MSDS and an HPLC chromatogram for high-value lots;
- Confirm MOQ, packaging and lead time;
- Request a sample to verify purity before scaling.
WYOO supplies Palmitoyl Pentapeptide-4, cosmetic grade, with COA and MSDS on every batch and MOQ from 1 kg. Contact us for a sample and pricing.